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Treatment of advanced canine anal sac adenocarcinoma with hypofractionated radiation therapy 77 cases (19992013). Outcome in dogs with advanced (stage 3b) anal sac gland carcinoma treated with surgery or hypofractionated radiation therapy. Excision of a right anal sac carcinoma, intraoperative views a (left) marginal dissection of the caudal aspect of the tumour b dissection is carried out cranially along the lateral aspect of the tumour until it can be rotated caudally, exposing the rectal wall (arrow), from which it is progressively detached by a combination of blunt and sharp dissection. Anal gland adenocarcinoma (aga) (also known as apocrine gland anal sac carcinoma adenocarcinoma or anal sac adenocarcinoma) is an uncommon cancer that arises from the apocrine glands in the walls of the anal sacs. An anal sac adenocarcinoma is an uncommon and aggressive malignant tumor found in dogs that arises from the apocrine glandular tissue of anal sac. The disease exists in cats as well, but is much less common in that species. They are the second most common cancerous cause of hypercalcaemia (high serum calcium) in dogs, following t-cell lymphoma. Anal glands are located on either side of the anus and normally produce secretions that are pushed when feces is evacuated from the rectum. An anal sac tumor is a tumor of made up of cells originating from the glands of the anal sac. These tumors can spread and therefore staging is recommended prior to surgery. To diagnose these tumors, a fine needle aspirate can be placed from the outside and.